	   SnapGene      +GCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCgccaccatggaacaaaaactcatctcagaagaggatctgGGATCCatgcagatctttgtgagaaccttaactggtagaaccatcaccctggaggtcgagcccagtgacaccattgagaatgtcagggcaaggatccaggacagggagggcatcccccctgaccagcagaggctgatctttgcaggcaggcagctggaagatggccgcaccctgtcagactacaacatccagagagagtccaccctgcacctggtccttcgcctcagaggtggcTAGAATTCTGCAGATATCCAGCACAGTGGCGGCCGCTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  2W                                       !      )                                                                                                                   %            $          (            "            "            	                                          1                     
                                                                                        
                              $                                                                                                                      '                                                                                              	               #   *            #                                        "               
                         "               
   ,   #                           !      %         ñ yfghmr�‚£ÑÚÛ€©	Q
QÓñ^à‘Íß yzœ¸úNŸƒŒ¤Pò0
5
I¶Ô1_áÞ¶†%�] – ò �inÜ�¿¬W	§Rò’7¥à · `æõ¹s®Ò�Òr	ª	
E
R
î¢t&ŠæÎe C “�ûOÒ„ûÉÕó[	á`‡ �;<�Ã#›²ú1
ç
}©Û2ì—ß¢â&¿F^n f{™ û‡¥Q		 	;	W
ã
ü
M�ÂÕâÄ�q·Ò‘Þ¸ z¹xâ	6
°¼J·y �D÷„Vjo«À­õX	Î	z¨óh·ÍkG8 $žåêsÁÝ²ÇWq–¬ó A~ — LmŽÆæiG	²	SžQhÏG“È¦á F ó þÕt:î
��“¾÷Õ! œ açî¥Àô«	
F
•
8H`­äç’eu«Ä*kŠç´£o…Ïf o ®õR©ö04t›£Ês	è	S
‰/9cJ) t 40\"‡¯·Óf‚¾�ÌÞ`	h	ƒ	œ	ð	ù	;
‡
˜
«
1£Èï£¾¥8'Û‹Àƒ ¸ +ìB¨ºÓaž¤ØO	ý	„ŸSÐ—çò D ü—Ó	 ‚·:…¾œ¢ÇÊÖ	^	æ	Kcfª7ˆ P´ë_a	\	v
}aÄ°`î M ”žc°Qü;âýfÀ.¦Jv X Ùt´ôÓ
×
ÞEŒÖ®ùI¦ë;´ ˆ ”<ŽÎ¿+
2
I
è
	ÛÜ˜àÈåzóãò'èG˜ 8=Ä³ûx
Æ
~Xš²3íni§ÀÒoÏõ ‹ íŒŽœÖ	qêªNÚb_wÄ  ‚¶ÅÈ$2	Ú	$ñ3è£¨  ° G?¦Ã	8	Œ	‹
ä
ý
cÃ6ú ½ g–ßÒãƒÅx�¨’¹ Ï |ˆ”ºGR[y.	<	‘…ž^¸ÆÇ  š¡«ü&Ì			!	X
¦
÷
 NÆÖ*r}…ÓßH�¯Ýßð Q]†Ùâ“Ýãõã	

E8i¸FY˜	 } É ây‘	|	½uvi Ö {rºCQÖ…n	7
™K�z{hC y 8CR«Á	Å	»
Y±ó]a€´E²r ‘dø…£kp¬	Ð™°øY	÷	{�«OiåËÎ õi E²àÁÅWÐ°ÿ÷5AH9 < > »ñW ¢®ö•	©®æ+slùg R ÚšÏ	
L
ÿô=£-¸ž¼³ú O ëÂSïÍÂþ±!Bu4 å %mŸæÊ•èÈXr—0ë2ý + `–½-ÞÑú|
	fvo³­íôiÈ 	 ³ ²Ë#VótÝ
L @ Æ äòø"
ÅŸL$aQT¹áïxët " ˜ Û j¨¸Ð±#?¨Éû§ Ÿ Mn ¤c¿õç%	¯ùR§i-�HPöFz1 û d_�ÇjH	—	³	

)=Tä¡¯
<ÂV7”Æöâ G ÇÖô
T}.:žpw ô T‰Ü3–ñMYp¤ê2 	¼	%
`
žb¿nä&Xˆ …ÿ²M;ï
ra”M­ eu(þ·ÿ?Ê	VÌhøÖ Jkè¦©Áò î	.
“
–
®åGÑ\f©°ÅµEÆm¶ V ® ŒG
Ä
Õ
Iaèg¬l¨F®¤pÐg � Ä bïa
Ã“m"+‹ã†/ T ¤ èõþ.6¤	¬	ì	
9;ÏZv—¥èLúdíJ›ç% ¯ S	¨-15“u˜ÇË™D	¦	ß	é	
T
 éŠ�£X[fïö¥ Z p à÷}Õî6åŽ
û0T£ÐýL¾=KU  „ öCHœ÷ÚÞ"&*	œ
Î
=!6DßFKd›   ªFnž¤@	t	Ù
/:
é$ J ¦ 5Y#8É Îv‚„	�	ú	
<
ˆ
™
¤Øð¿Þ¤C”¦'û#(I> è e 9]ˆ!¶a	i	ñ	?
¬
µÉˆºÜ*]  8 u ‘ © )1o¸EgœÍßöS	¢
jˆà÷¤Ž&€½ê,Œ„9(  1 ¬°Ô<uƒ¿ì‡	
m
2¿xˆ™¹9\›§õü$›¹ÁsŽÍ{µ  C©cXŸ¥P	�	’	N
s
ë
!n… Ž»Øºßè"óR ' ¹ rÆyçë*ZÔþ	-u?Tƒ�Û;W+�ü 0ñ|ÑÜb¨®Ùf&0‘íöÐNÑd	" ,<J¦ÏíýÕÛ»ùê08ÚîDPYeoz®	Ñ	³
Alë">A˜� • xMô
¸€ÙŒ¾O«¨	4
ßµ‰å\d¤Þ ˜ú;w†È		á	V
û
L»ëxœpÑÝE E ýÔƒUôF	�g «" n s › í!/3š¿½É�£Ë×Ý_	ç	07dÃ 7‰³8b¢I –^`b�¶›	]	Ý‹be¥¿- Š “µÄì‹ÇÍ¾w
Ùðäçhyñça§Î ¼ ª>•7	~‚]|ÅÞwÆ5ï	 QP�â	{	À	u± Q ºß¢™ÏÄK
åþÊŸ4�ôøf²ù  * N ä l•±Ê"URÐÁ{
ì/3êK ! Ú ú Ÿã§i<ãK	Á
õ"`6>E§îwõ 2„d±ý¶éþ1>-agW j`ñý-5£	ë	-
Ã
Ô
ÂFfÎ¯â§DEìÅ.µ Y �|—ÆÙí!5Ø
5ÞúJŒ¢WZÏ¤<š d Xn7Ítuµëõ
ß‡�£B¸šô"#)�Ì & ÚÐêê
 ×ì@�ÚÞ m r ùN3
6œÂÿ
o´Ðä¡ÜH[c ‰ •=�Æ	6	¿	
Üï�tæx{4 ¹ÉƒµÏýÀJ
z
ä`Éôó2éíV±ø % c WmüsØ ê,
Â
é
e4Ýë™á!V(Ä™ Å´×üéy
›3ãêÁîþ	€nÏÃ°Z÷1 \ ¯Â†‡5±²³mno�‚çèýRSjklm¨ÍÎíîÀÁÂ¯ÁÓ?@MWXYÐÑö ] 'è°Ãâ96>zpƒ€Y&/³TèïûNpÒÚ ¡gˆÃ´Ç
Z4o26©ÕÂÔAÖ (ZŒßé]™Äãî7q�×	�
�ëZ	cúKð)¥OqÅ á Wu>2”r0ÊÒBc‹•`x�ÓÛ ^ € ë :�?„�“å-‰'´Åé  Œ ç ±{	«—OÛUü 0
 @oµ‰Wæ¤NšÃ j ÌƒW%(~3	x	È
Ïò™é3B× ¢Ïh‰½µJ_Û	%ô[ZÕª{ÿ©Õ !·ÆÄÉ/ð8p5p4l7ÖRÿ 
)�êB^šä@µÄ9	…
å
^x‚ì
›�% † [à8r	,	l	Ø	þ
[˜ÄûLÂñ¦­² ± bÅïždpõ¯·ûrÆ  ÄûH¦ž§ÓÜ$—�	Œ
‘
?dÜ*)7kP  â ÿ jvhK•à<À¡5ò^Cd¢Ü X3L1áä~yÓ“aÔ ¾ Â—üsÓ
�¾ À ?ž
xÒË„Æ‚©Œ–yº � Ì Ó NƒÖ�Úè@J‰f/	=	B
ÕýµqZ¼•ª Ð Þ ì ÷ ø/<;ù»�æ.HŸ_Çê’ _ ˜}•HS\z…Š“	€(8ï¹QÈ�ÀÊí Ž\a?”s¹d	·
’†FÆ‰[ 65E|×"	€	ô	Ë
Ð
–#-¬PV^€fÞ è ¶¿Z²ÊÍ	‚
ø
u¸x!`m˜µÜMÊý1Ìžþ¹¡   - � 'Ž›¬'î5à(
	Y
c
O×hös†Ô@I“à ¢ýZ™àTþ~
§
Ç»ÓS+~àZ°.ñ µ ï "œãw¶õ¡ä
FÍÙ�„Žl
 AAä	
9{ÔG1y¥› R^‡Ú+”]Ëö 
Û
¯OÄ Â pÍÞæŠB	 
j¹XçZùb™·q  z	y	×vš½ê `C  h k ~ Í„U’&4	v	}	$-ÃÍP4Ø Ê ´%XXÉ
¾Ðó« ¼ë ã$)Ëwßj £&-¾×% o	Ü	(
8
&šAŒ†“#D
 × HR†{[Öá| |ª»i&¶õ| ª%  sÐDŠ+K`ß
L\�½«iNÖ{� z 9vÂ	²ô^‹zÁF;«½s˜å ?¬|ÇåÊñ9¼
¿
b†8&�×S+ 	¸p¦Æ	h
¯
q�6ÈÚ<ÿ D‹"SÍHiÅ¬0ZÌïqµ5m³  Ž_›åùželq‹¢­ÐÑV	q	D
¦íP¡ðs%6 B ’e€Ñ:ú"š±ùÔ:	Z	æ
|�Áà–¡¾ CrÀs
ÅhyPœ•Ìò@½öj}F&$ *3­ëôQ¨/[A†¤¶€ø	ü	:
†
_ƒž¬Çã‘)jæˆÏ–‚ñ L ³ê9P½s³Æ	Dü øeÃ6I_í:³ ‡ 1	Õ	Ù	*
Ú™±MÇòv—Ã  Î F%Ë¹ÂÞFx	-	‹	Š
¥
ÿ
ÑÅ)„§® x È Õ 7P\…Øáq’Üáô„m	Xò7\ŽE—gB ; = ±Ù˜Ÿ¡¯÷
œªN­¯ö*,»@ ² ¼òîùeuçý°thüÇ ? c£ñô–	(ø¦·®OS¸úês ÆðL'LX£Ÿ	»	É	$
_
ó
Uq9ËLmã%¬ S £ I¨
’
l–¨¤KùIl ƒ §,m’BÔÝ%˜ä?	Þ	�
›
ÿCE.S¢ü½	  0 7 � ¨ (Ÿ›†	
>
l
i× Ý&¹ +Ÿ\8z´   ¥ÅüÛæø)W­Ž	Ð	M
r
²
@emtõ!>¹c!V*€Qû ” š wìLTØ‹½ªÜ6ÿ²Ý ÃŠµáŠãÝv,Í   P Ù ã ù k1â˜Îè0=ÃJ_5De  i_–ð4Á†¢ó¡"CË£ $ b lûMs³1ì3b & çfÂ4yl2âéçìúÔ®Õ à æ Y=1
’ˆ–ùJÉ/A” nË¼}ˆI^åY˜Ôzþ 	aÃú´Ò–k	—®€
j$ ¿ JKûw}	 Ò Ý —Õ.;`>e’¸c	A
ÔüpîP‘”©¿É , ¾4˜ß4ýó	}
t·
,glº´ÒR]õÉ?Ëý  ´ Á î !›Ì*ô@ Ÿ
ÓÌØaŽ~ƒ� 
 g ³$WT#¼Þ_ª» ,Þ
"M$z€ >u®
Ëy…ÀÇ%�ª—ä A ¬P§qŠùgÓU	C
Æâ �rñ¼|ð½ w Ç Í Ô O„×p‘Ûé¸óE0	¤
6dÆ(ƒìu–Â : ¢°óKøº	#
ò
÷MT¶NRºâ« ‚ ¢ +å÷A(Vã>	
k
lÖþk%Rb HU[y “ ™ ø 0Š—¼©ç/ ÊÌ # a ß <ek»Áú	k|‡‘I²æëù.@­ Ñ Ü ù3J‘•ûk¹ÑQ~ÈÊü	“Ÿ¨ í  š=+Ÿ¿`$Ž©!ã# ¡ Oo¡¦¯*öòDUÒâ¹	SjðMQ‚»G{Á ` ™dÀ‰–žI{†�”úåøÉ¬"žË'   N¥èéCT‹Œ�Ž�ÏÐÑá	·	¸	Š°9:;<./IJKL‰ºä÷;!‰Š ~~½,AGTiê]	&	‹�±)=¨(0ŽÓìŠR<'2‹î « yB`ë^	'	e	¸
*U‚¦è¢ÛS8ÒÊ÷ ü È“*>=×W†Š(Œ �ß]bºHU@•tI	´	Œ)3>A”åGÔíÃ‹=\Ç3  e¾	-KPj�kº˜	
ù‡²©Ç)|‚1�°•…ãï }8_	f	�	á
§/Q›£ÜÓË 6×®Ô©
¹
Ñ
õ
—Vƒ~Wø È#	õ	RUý­;Ÿ¡_Tqguxß H ¬ 7zFCXaØì(	Ì
+$.é†’�9  ‘òNÎ¥ë3¡	ù
¹¶Ýc>�2CÍ‹å¢ é UŠ·Ý[—³q-ã+	½	4a¿^vËþŸP‰Ú� õ ý À4ŒZa
ƒ
v”Ú^n™ŸðÀX‡'Y·º}° uFËÉ&
f
y"+?Á	Š»N÷­Ø»oÿ)   . Ž œ�ïNc»–«±	‰	�BNs÷þ•J”>]4 ( ³à^²Öw<*•H„ŒN ­(IAµ	ð
4?æizbÄ&‡Õ}Èáƒ  †�V6á)uJ	Z
d
PØ©ÕîtAØ® Ò‘MblwL	™	Ë	¨
³¼};±ÍT,�Ú/ä €€ˆ¿£þ[fšÿ»ÿ
ˆËWÈ*Ô2i[Ãò v
).>Q
\
o
úÈªƒ«áùÏ×† 3 fþ!áLk…¸Á 	@Uî��×k–±ð ¶ ð x·~ñ
/
P
HµÒ0]Ý�…$�Ì Â	â
¯¨ÚÃám· #�äKléöªå9±	Í	í
gœ±ÆÎVp¶F’ÇÔ §óe¢`N	g	‚	›	ï	”
—
ª
G¢æ½R¤ªÚ.¿n„ W Ø¯¡å	u
Ò
Ö
J:|Õ­H©¯ê¥u 7�H
Å
#péWm2¦Ñô ¯ “Zö
b„G€œÜù | BBÕªÄ	

º
D˜`hXt³Dzqh cð”	ö	VÏþ<¢ärh	 _,ÉÌÜ
”n1 ž Å b¾^÷$		
!
Ä® #,Œ;°UPyàÅ0 SˆÛ•oS|`ov‡ U ­ Ã çÿ‹í	:ÐY[!c­šæ  ßEGö)	C	¥	
Í
< èeîKõTè# I ¥ 8«È ;DR	¡
‡´ö¾%w‡“˜[¦¼éúHû=š¸rç* /;IqÎðÔx{é/7YbÙíCOXdny§‘	­	,%/k��ºê=ÏM‚:œ ó .2v™¼Èó	E	§	à	U
ú
/ºÞêwˆ›aD£ » 
’©O]€”Ìš½z	Ød¤¾\gÅðæ¦  ) ° !TÞ¡¦h,ë	ž!3œ=÷ô# 6œÏé{Ì,Åì4¢	ê	
ÍA·?‹ŽYDÎÙÝŒ- l q ¸È‚Vø~r	5	¾	Á
5d_ Uw UÛ [ ®Áá…°€Öæ%.YÀüQ15Ì¿>LVÙ   ê Vt‹Þ\˜“ä,~	�
bÄÿ(¤ÑŠŽ i ?´ÎV'.ï7w	oóÎVkþM™Q … A~¥�Û#~+	„
>]wÛošôÁ¬¶(±  þ iÁ;�
¿ Ñà4ñ]¡~½ Ë ö M‚÷�ÙçI[ør	¶
7EGYˆZ»œì  µ&5Y�ÉYíDÖß'Sb
�
Ê
Ï
•"w _LY’e-¸ vå\ÊA	 
Ú
zø0x®¶pk Ÿu	#,ÂÊÌ
ÖOŸê  ©%G$%*'
@‹¼…’à  Š«{ÌäGho¥g
¾
Šî:Ù;¼*þ" 2ó.Z�¿Ð9rd¡Ï!p	û	9
Ž¥OÀßï(•$‡”?•E5  K 6$ÊO¼Ýwƒ²	Š	Ô	)
‰
ÙñC�D–f^ KØð&í—ž	È	
^
'›t¥¬8­Êü)K$?é  / 6 � § ¤'l‘¬…	Ý	=
q
š
±
hsB D•§¸Jøÿ¡û Ø ^‰´á×3ÛI…‰âÜ+
 0xH]‡øÓ Ô:I_³3=d·b	j	ò	@
¶+–|\>O# f )S"­
Ê»×Ý�}^ 9 v «p'·÷T	
j
£
ñ
ká5ö�cÅ'~ ’ *2jºj¾P}-� â  }¼®)+@FShˆ�ñBÎà¶	‰'Òë�ˆã:« &ˆ ª xÞ¹JOø(2@“¥ç{�ÚÖ…ÑÉ„ ­ÓW¨7
à
Qü…‘š t"  tE‹�~,â*e
3Ù]À‰º¾]ïöuœ¬BºO¶Ù|¯   ±Õvª°ˆ	Mƒy¨ý%|×‚ 2 ‡Ñý =„ÀLavíK	[
n
Ê:œªÖjÂ�ÎÙ dðM	š	°	Ì	O
©
ì
¡´¼ÙÂUo-¾à#‘ƒ { ’Y Ã	t
"Co_s²CéÛtó
 ½n“	Î{:n0,  .:HïÓwDªÇ:BNWcmx¦Q	�	†³õŒ�½$~ <»ÎG<¬ô™æSå# ( º ÿÝÿ\›èË+»Äòg¼.Ì+@‡›ÄØÜ<ó, >sÇ�­ÀU¯À
cnòXUj'˜T Lh�@ŽØ}¤ÈæìÕ:Rq} 	€
µ
\v3\‘Xµ, ¨‰$zg#ä[ ÿ	½
‰íÉÕ„‘9µžý 5 1òÏJkqìÜÇ	Ó	]
p
°
gr«î7C”¬·Éeú  Ó/22cG\Ú÷ÒÛ=" 
¹wÝ*?NR‡ð
i
'1’ÑÙO€âÐ‡ }Òü§©¯ûÉ‚„Ÿ
Ø -Gî¼Æ9mAVï¯	BÍ#r9Bnm‚ò! =Kg§þ�×#TÜ"ã®ºÃQfp|´
[mìñš´—´ 4 ÒÎIjûë1M†Ûï1F[Ò	B“ž¶Ø!% EFÐÑŒÖúÿ âl­¹Â
EZ{ð?@A‘’678l™²³ñ   +f  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                             #                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           	                                                                                                                                                                                                                                         #                                                                                                                                                                    
                              
   	   	            )               
                              	                        
                                                ,                               i   H                     G                                                                                                                                                                        #                                                                                                                                                                                                                                                                                                         	                                                                                       #                                                          
          
 	 	    )     
          	        
                ,           i H       G   f4  g  g8  g^  k  nÞ  t
õÁ	YÊÿkë1x“	³ÌU»ÒhËû) Ž
ŽÀq E,¦íßÿ¢E		û`Õ� ,¦ÆíJb ¸õ÷!<ZÕPŸ¥�	ñ	
“
™
2alím°"[ßÈ›\é
šX
h²šQX
v
hšX
hšX
šššX
š		A]ek»û‚£üîgq¦q	÷
 &c¿¬‘ x	Û¯pñ¸Ï				ÚzÓþ³þJ×Q†Ù“v}
I¯
qD	sK©s£«	Î	ó9ª:½E®´NÃA§N	ü	ƒžRñ] Œƒ&)
ÙQ†Ù“«	i¸…jÂ ó× 
×
-³(-(­ï¹Þ ;�HÚU]¹r	Ï	-(ü	 ûÙ¹®Ò�zü «	ŽœÚ"=Þ|
Ä¸Ë	o	þÜfšI‘íÝ	ü»^-5«	uçª©s û¹‚Ž£¾«	Î	ó89—À“áÐßÊÂc3]uÙÜP°*ÊÚ
@}Îº} ÚïO
\î“DË	ÁT�Ž
£Ycë
 »½9Ç§N	Ã Î¤#l§N	œDÜq@}}\¬ Ù¹®Ò�r	Ï	
×
-³(À°óv@}}Ú\y‚”	ÛV ,íY]-1ç˜œ*8cÇÚ"@	ú	Õ
9=fj »"?¬'TÛ@}}\œÚ"=ó*™ ªû	W
MÕq|ÒÞÞï® a5DÖÊ
"ö%@ïdÀåø¬À­ÒMblw;Í–Ð)
ÙßÊÂÅ‹YÿŒÜ$ÁÆ }mÆ ŸñeÇþv}-(¬ [³»	½	ù
U�¹4y/ÜbÄ&vÀÃ° Â ±i@ øc »6ÇÌ
AG<æŸs
è­‘Ý	6Ì
A}j­3]cuÙ�õ
y Á	]r8›ÓŽV	¦6 ±"UK[†hÇ³™ û	 	W
MÕqÒÞ¡ü¦
Æ*}ß¯ð1òÏÿq»ò.î‡”…­P	°¦ 5„	é	
<
™
 C”¦IŠ�X · +ìt¹ºÒ°—æ÷Õïð¯	O
´n#‚DÀG8Ëf
Ø»)t°÷Õ5é	
 Š�X¦ „	<
™
C”¦I ÈìÕR€
v‘,?Ã8	ä
¡FÙ’	 ¦ 5C¦©ò ¥P	„	�	é	î	
<
“
–
™
…åŽ C”¦©ºIŠ�X ómR1òÏÿq»òïð¯	O
.´î‡”n#‚CÞ&Î
!Kd G¦Œ	‹
c6-¾ o	8
†“D( ÿÝg+›<ó¥	ã
ü
ÂYSY- �~œBK O¼²C^y¸5
I¶·ÿ?"œãõ ×%ä&šzÍê # K ’ �~O¼²CœB^Þ¡ž3œ÷%$'
@‹…’Ýi¸Y˜†-GîÆ9AV#.
GÑ\‹ rCc°ü‘K…ªN�Úfh

DSh|Xov ‘NN»‘±		‰	á
B§c±•Úå]wÝN'1’ÙÐ2
ãGmÊà%
WX—#n¨Aýˆ ”<Ž	ÛåzI?æzÕÈƒc°üfrCK�hà%
WnA‹ ‘…ªNÚ C¦©ò ¥P	�	î	“
–
…åŽ©ºómR%Þ¡$'
@‹…’ž3œ÷† Ø	˜Lñü “W†l
/U ­ Ã çÿ‹í	:ÐY[!c­šæ .:HïÓwDªÇ:BNWcmx¦Q	�	†³õŒ�½$~ <»ÎG<¬ô™æSåJkè¦©Áò î	.
“
–
®åGÑ\f©°ÅµEÆm¶	 ³ ²Ë#VótÝ
Ld Xn7Ítuµëõ
ß‡�£B¸šô"#)�ÌT ¤ èõþ.6¤	¬	ì	
9;ÏZv—¥èLúdíJ›çØ ^‰´á×3ÛI…‰âÜ+š¡«ü&Ì			!	X
¦
÷
 NÆÖ*r}…ÓßH�¯Ýßð¸ +ìB¨ºÓaž¤ØO	ý	„ŸSÐ—çòdðM	š	°	Ì	O
©
ì
¡´¼ÙÂUo-¾à#‘ƒ… A~¥�Û#~+	„
>]wÛošôÁ¬¶(±& d t ¸ +4ì0X\nÚ"7B‡¨ºÐê¯·ÍÓft‚Óau¾�ž¤µÌØÞëõO	`	h	ƒ	œ	ð	ù	ý	
;
‡
˜
«
ê
 1„Ÿ£Èßï£¾‡�£×ìBS¥¸8šô"'@�ÐÛ#‹—ÀÚÞç)ƒ�Ìò … ¿ þ 	aiÁÃúAJ~¥�´KÒÛ#;~–û+	k	„
�
>]w¿—Ûowš Ñàô4}ñ®Á	]€¬¶
(j¡~±½$R^‡Ú+”]Ëö 
Û
¯OÄƒ §,m’BÔÝ%˜ä?	Þ	�
›
ÿCE.S¢ü½	)^ € ë :�?„�“å-‰'´Åé}Òü§©¯ûÉ‚„Ÿ
ØD ü—Ó	 ‚·:…¾œ¢ÇÊÖ	^	æ	Kcfª7ˆ# a ß <ek»Áú	k|‡‘I²æëù.@­E d R^‡Ú	+”ýXn¸Ô7pƒUÍ]t¦ËöuôµëõF	Æ	
 
h
¯
Û
ßq��‡�£6B¸gšÈô "«#¯Ú<)O�ÌÄÿ6×®Ô©
¹
Ñ
õ
—Vƒ~Wø   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="15"><Feature recentID="0" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="890-899" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="1" name="Myc" directionality="1" translationMW="1203.34" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1165" maxFusedRunOn="1165" detectionMode="exactProteinMatch"><Segment range="899-928" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Myc (human c-Myc proto-oncogene) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="EQKLISEEDL"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5436" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4645-5436" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5437-5505" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="3" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2349-3143" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3889-4474" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1511-1939" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1953-2282" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1241-1465" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2133-2268" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3317-3438" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5506-5610" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="ubiquitin-K0" directionality="1" translationMW="8761.18" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1165" maxFusedRunOn="1165" detectionMode="exactProteinMatch"><Segment range="935-1162" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;also known as ubiquitin-KO&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human ubiquitin variant in which all of the lysines have been mutated to arginine&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MQIFVRTLTGRTITLEVEPSDTIENVRARIQDREGIPPDQQRLIFAGRQLEDGRTLSDYNIQRESTLHLVLRLRGG"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¤<Notes>
<UUID>37d40d4c-4fc7-4bce-9df3-aa1e74eeb33b</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-Myc-UB(mouse)-K0-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="1:37:31">2025.9.21</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                             '<StrandColors><TopStrand><ColorRange range="0..933" colors="black"/><ColorRange range="1076..1076" colors="magenta"/><ColorRange range="1162..1880" colors="black"/><ColorRange range="1881..1882" colors="magenta"/><ColorRange range="1883..5673" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..933" colors="black"/><ColorRange range="1076..1076" colors="magenta"/><ColorRange range="1162..1880" colors="black"/><ColorRange range="1881..1882" colors="magenta"/><ColorRange range="1883..5673" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
